Individual
DC projects

Research project

Nuclear propionyl-CoA as a mediator between nutrition, chromatin regulation and cancer cell proliferation

Rationale and objectives:

We have identified propionyl-(Pr)-CoA as a major acyl-CoA species in the nucleus that responds to nutrient perturbations. We will develop methods to study the role of nuclear Pr-CoA in cancer cells.

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Therefore, we will:
• Determine the nutrition-sensitive variation of nuclear propionyl-CoA concentrations in cancer cells.
• Identify nuclear enzymes impacting the abundance of propionyl-CoA specifically in the nucleus.
• Assess how nuclear propionyl-CoA impacts histone lysine propionylation (Kpr), gene expression and proliferation.

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Envisioned Secondments

UMIL (Bonaldi) months 15-21 (4 months) to receive training in subcellular quantitative proteomics. P4H (Fernandez) months
40-42 (2 months) to analyze data and blood samples to identify factors associated with Pr-CoA levels.

Recruitment

The estimated annual gross salary for the fellow will be 41.000 GBP without family allowance; 45.000 GBP with family allowance (approx.).

 

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The successful candidate will need to register to the University of Cambridge via the Graduate Application Portal. Further instructions will be given to the successful candidate once the offer has been accepted. All of the Babraham Institute PhD students are registered with the PostGraduate School of Life Sciences at the University of Cambridge and have a personal affiliation with one of the University’s many colleges. The colleges often provide accommodation for their students as well as additional social and pastoral support.

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