Individual
DC projects
Research project
Assessment of genetic background in the epigenetic response to metabolites
Rationale and objectives:
Genetic variants of metabolite-sensitive chromatin regulators and metabolic enzymes providing their co-factors are likely to influence how diets impact on cellular metabolism, systemic health and disease risk.
To test this, we plan:
• To evaluate the association of single nucleotide polymorphisms (SNPs) in ‘epi-metabolic’ genes on phenotypic traits.
• To test the impact of disease-associated SNPs in liver and muscle cells on redox metabolism, gene and chromatin regulation.
• To validate the influence of DNA variants in the response to diet interventions recruiting volunteers.
Envisioned Secondments
IJC (Buschbeck), month 31-36 (5 month), to learn methods to analyse gene expression, chromatin modifications and structure comparing cells carrying disease-associated SNPs and control cells.
Recruitment
The estimated annual gross salary for the fellow will be €31.500 without family allowance; €37.000 with family allowance (approx.).