Projects

The impact of nuclear NAD levels on transcriptional regulation and DNA repair

Universitetet i Bergen, Norway

Mathias Ziegler

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Impact of nuclear localisation of enzymes on acyl-CoA-mediated PTMs on histone and non-histone proteins

University of Milan, Italy

Tiziana Bonaldi, Roberta Noberini

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Visualizing acyl-CoA and associated metabolites with subcellular resolution

Leibniz-Institut für Analytische Wissenschaften, Germany

Sven Heiles

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Investigating the 2-hydrohyglutarate (2-HG) protein interaction network in leukemia cells

Stockholm University, Sweden

Ilaria Piazza

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Computational analysis and modelling of acyl-CoA metabolism and protein acylation dynamics

Universitetet I Tromsoe - Norges Arktiske Universitet, Norway

Ines Heiland

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Uncovering the role of nuclear acetyl-CoA metabolism in differentiation

University of Copenhagen, Denmark

Jan Zylicz

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Elucidating the impact of metabolite-binding by histone variants in gene regulation and chromatin architecture

Josep Carreras Leukaemia Research Institute, Spain

Marcus Buschbeck, David Corujo

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SCFAs as regulators of cell specification through epigenetic regulation in cancer

Universitair Medisch Centrum Utrecht, Nertherlands

Maria Rodriguez Colman

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Metabolic crosstalk and nuclear acetyl-CoA metabolism in the hematopoietic niche

Stichting Radboud University, Nertherlands

Peter Tessarz

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Assessment of genetic background in the epigenetic response to metabolites

Precision for Health, Spain

Cristina Fernández, Marta Gómez de Cedrón

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Modulation of NAD+ -dependent PARP1/2 activity on chromatin by regulatory cofactors and impact on cancer

Eisbach Bio GmbH, Germany

Andreas Ladurner

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A functional genomics approach to assess nuclear essentiality of metabolic enzymes

Centre for Genomic Regulation, Spain

Sara Sdelci

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Testing chromatin-bound metabolic enzymes as vulnerabilities in acute myeloid leukemia

Josep Carreras Leukaemia Research Institute, Spain

Marcus Buschbeck, Florencia Herbstein

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Metabolites as epigenetic substrates drive myeloid lineage bias in aging individuals and AML

Karolinska Institutet, Sweden

Andreas Lennartsson

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The role of histone metabolic reservoirs in liver cancer

University of Cyprus, Cyprus

Antonis Kirmizis, Evelina Charidemou

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The role of repeat elements in fat induced chronic liver inflammation and implications for NAFLD and HCC

King Abdullah University of Science and Technology, Saudi Arabia

Valerio Orlando

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Nuclear metabolism as a mediator between nutrition, chromatin regulation and macrophage function

The Babraham Institute, United Kingdom

Sophie Trefely

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